In the few times I played Dortmund on career mode, I tended to end up with this team. This setup is best for Dortmund because most of the players in this setup are already Dortmund players and the other players I offloaded could pay significantly for the rest.

Meticulous rotation is necessary for all players to be happy (so simulating matches would not be helpful since you have to use all three substitutions for every game to get as many players proper game time and sim matches don't do substitutions regularly) and so far (in 2 and a half seasons) I have not received any complaints over a lack of matches. Only my Starting XI would receive "Important 1st Team Player" and above in their contracts - the rest would be on "Squad Rotation" (and lower) or they are already signed by Dortmund.


Instructions:
All CBs: Aggressive Interceptions, Stay back for attack
CDMs: Aggressive Interceptions (CDMs will become LWB and RWB if I fall behind in a match)
CM: Move up centre for cross, Conservative Interceptions
Wingers: Stay wide for cross, Cut in to assist central attack, Stay Forward.
CF/Second Striker: Play False 9, Stay central for cross, Conservative Interceptions, Stay Forward.
ST: Get forward (pressure the back line), Conservative Interceptions, Stay Forward


Roles (from first pick downwards, depending on injury status and setup of team according to the importance of the coming match):
Sent on loan if possible: Alexander Isak, Emre Mor, Erik Durm
GK: Jan Oblak, Alban Lafont, Roman Burki
CB: Sven Bender (captain), Marc Bartra, Matthias Ginter, Lukasz Piszczek (vice-captain), Niklas Stark, Erik Durm, Mikel Merino
CDM: Joshua Kimmich, Lukasz Piszchek, Raphael Guerreiro, Saul, Mikel Merino, Niklas Stark, Erik Durm
CM: Saul, Leon Goretzka, Raphael Guerreiro, Joshua Kimmich, Niklas Stark
Wingers (all my wingers can play on either wings): Marco Reus (third captain), Ousmane Dembele, Christian Pulisic, Andre Schurrle, Kingsley Coman, Oliver Burke, Emre Mor, Julian Draxler, Mario Gotze, Nadiem Amiri
CF/Second Striker: Julian Draxler, Andre Schurrle, Nadiem Amiri Marco Reus, Mario Gotze, Kingsley Coman
ST: P.E Aubameyang, Angel Correa, Alexander Isak, Andre Schurrle, Mario Gotze, Emre Mor